In the "There is a good reason to believe there is an afterlife" corner, we have two Rabbis - David Wolpe and Brad Artson. In the "No evidence that an afterlife exists" corner is Sam Harris and Christopher Hitchens.
If you have an hour and a half of your life to spare, there are worse ways to spend it than watching this video. The debate itself is great, because Christopher Hitchens. Also, and this is sadly rare - the two sides actually do engage in a discussion with each other. It's a good natured and funny discussion too - no bile to be found.
The full debate can be found here.
If you feel in need of a preview, here are a couple of gems from Hitchens, to whet your appetite: